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Longevity pillar · Singapore

Epigenetic Biological Age Testing in Singapore

您的DNA序列在您的一生中几乎不会改变,但附着在DNA上的化学标签会随着饮食、睡眠、压力、运动和环境的变化而不断改变。读取这些标签可以告诉我们您的生物学年龄,它可能比您的实际年龄更年轻或更年长。

  • SMC-registered doctors
  • MOH-licensed clinic (HCSA)
  • Mandarin Gallery, Orchard Road
  • Weekdays 10am-7pm · Sat-Sun 10am-5pm
  • 个人健康礼宾服务

测量内容

生物学年龄

根据数千个特定位点的 DNA 甲基化模式计算得出,估算您身体在分子层面的年龄。

年龄差

生物学年龄与实际年龄之间的差值——这是患者随时间推移追踪的核心指标。

检测原理

样本

唾液或血液,在单次门诊访问期间采集。

周转时间

Your personal health concierge confirms the reporting timeline for your laboratory when your sample is collected.

方法

在数千个 CpG 位点进行 DNA 甲基化分析,并通过同行评审的表观遗传时钟(GrimAge、PhenoAge)进行解读。

为何选择此方法

我们不依赖单一时钟。我们综合报告多种经过验证的算法,以便您和您的医生能够区分信号与噪声,并在 6-12 个月后通过基准测试与重复读数跟踪变化。

您将了解什么

  • 您的生物学年龄是领先、落后还是与您的实际年龄一致。
  • 您目前的衰老速度。
  • 您所做的生活方式改变(训练、营养、睡眠、压力、补充剂)是否真正改善了您的生理状况。
  • 哪些系统可能需要更多关注。

Why biological age matters for healthspan

Healthspan is the number of years you spend in good functional health, as distinct from lifespan. Epigenetic clocks were built to estimate that biological trajectory: they read chemical methylation marks on DNA and compare the pattern against reference populations of known age and health status.[1]

Second-generation clocks such as PhenoAge and GrimAge were trained not on chronological age but on clinical measures and outcomes, and in published cohort analyses an epigenetic age older than chronological age has been associated with higher risk of age-related disease and mortality.[2], [3]

A third-generation measure, DunedinPACE, reports the pace of ageing rather than a single age figure. It was developed from a cohort followed over decades and expresses how many biological years you accumulate per calendar year, which is the measure most sensitive to change between two readings.[4]

Methylation is responsive rather than fixed. Small randomised and pilot studies of diet, exercise, sleep and stress interventions have reported measurable movement in epigenetic age estimates, though the trials are early, small and not yet proof that changing the marker changes the outcome.[5]

These findings describe associations observed across populations, and epigenetic testing is a research-derived tool rather than a diagnostic. A result is a starting point and a way to track change over time, not a prediction about you as an individual.

Reading your report

生物学年龄

Your estimated age at the molecular level from each clock reported, shown next to your chronological age so the direction and size of the gap is clear.

年龄差

Biological age minus chronological age. A negative gap means your methylation pattern resembles people younger than you. This is the figure most patients track.

Pace of ageing

Where a pace measure is reported, a figure near 1.0 means roughly one biological year per calendar year. Above 1.0 is faster, below is slower.

Multiple clocks side by side

Different algorithms weight different sites, so they rarely agree exactly. Reporting several together shows whether a finding is signal or the quirk of one model.

System-level signals

Some clocks report component scores that flag which systems are contributing most to the gap, which helps direct the rest of your work-up.

Doctor's interpretation

Your result read against your bloods, body composition and history in the action-plan session. A number without that context is not a plan.

What moves the result

Sleep

Consistent duration and timing. Short and fragmented sleep is repeatedly associated with accelerated epigenetic age in observational cohorts.

Aerobic fitness and strength

Measured cardiorespiratory fitness and lean mass track with slower biological ageing estimates, which is why VO2 max and body composition are read alongside.

Body composition and metabolic health

Visceral fat, glucose regulation and lipid status are among the strongest correlates of second-generation clock output.

Nutrition quality

Dietary patterns rich in vegetables, adequate protein and methyl-donor nutrients feature in the small intervention trials reporting movement.

Alcohol and smoking

Both leave clear methylation signatures. Smoking status is directly weighted in GrimAge.

Chronic stress load

Sustained psychological stress and its hormonal consequences are associated with faster estimated ageing.

适用人群

  • 任何进行重大生活方式投入并希望获得客观反馈的人。
  • 正在接受激素、代谢或长寿治疗并追踪反应的患者。
  • 40岁、50岁和60岁以上正在制定可衡量健康跨度计划的人群。
  • 管理训练负荷和恢复的运动员及高绩效人士。

何时复测: 在积极做出改变期间,每6-12个月一次。单次读数只是一个快照;价值在于读数之间的变化。

它如何契合三大支柱

没有任何单一测试可以定义生物年龄。 表观基因组 与另外两大长寿数据支柱相辅相成——每一项都能揭示其他项无法提供的信息。将它们结合起来,即可获得当前医学所能提供的最完整图景。

Included in these tiers

Every tier includes a pre-test consultation, sample collection at our Orchard Road clinic, laboratory analysis, clinician-led interpretation, a written report and an action-plan session.

查看完整 长寿筛查套餐列表.

常见问题

表观基因组 - 常见问题解答

由我们的临床团队撰写的清晰解答。点击任何问题即可获取其直接永久链接,如有其他疑问,请联系您的个人礼宾服务。

  1. 表观遗传时钟的准确性如何?

    我们使用的时钟均经过同行评审,并已通过数千个样本的验证。任何单次读数都存在一定的测量偏差,因此我们建议在进行基准测试后,于 6-12 个月后进行复测,以衡量真实的生理变化而非测量误差。

  2. 什么会影响我的生物学年龄?

    已发表的研究表明,睡眠质量、训练、营养、身体成分、压力负荷、酒精、吸烟、代谢健康、激素状态和某些药物都会产生可测量的影响。您的行动计划会议会将您的结果转化为对您而言最关键的改善杠杆。

  3. 这与健身应用程序中的“健康年龄”相同吗?

    不相同。可穿戴设备和基于问卷的年龄评分源自间接信号。表观遗传年龄是直接从 DNA 上的化学修饰中测量得出的,这是生物学中一个本质上不同的层面。

  4. 我应该多久重复一次测试?

    如果您正在积极改变生活方式,请每6-12个月进行一次。如果您处于稳定的维持阶段,请每年进行一次。

  5. 这项测试能诊断疾病吗?

    不能。这是一种长寿和健康跨度追踪测试,并非针对任何特定疾病的诊断。检测结果可促使您的医生在必要时进行进一步调查。

  6. What is the difference between GrimAge, PhenoAge and pace of ageing?

    PhenoAge and GrimAge were trained on clinical measures and outcomes rather than on chronological age, so they estimate biological age in the context of health. Pace-of-ageing measures such as DunedinPACE report how fast you are ageing per calendar year rather than a single age figure, which makes them the most sensitive to change between two readings.

  7. How is biological age different from my chronological age?

    Chronological age counts birthdays. Biological age estimates how old your body looks at the molecular level based on methylation patterns. Two people born on the same day can sit years apart, and it is the gap and its direction over time that your doctor works with.

  8. How quickly can biological age change?

    Published pilot interventions ran for eight to twelve weeks before reporting measurable movement, and cohort work suggests meaningful shifts are best judged over six to twelve months. Anything measured week to week is noise.

  9. Do I need to fast or prepare for the sample?

    No fasting is required for a saliva or blood methylation sample. If you are recovering from an infection or a period of acute stress, your concierge may suggest deferring collection so the baseline is representative.

  10. Are epigenetic clocks validated in Asian populations?

    The major clocks were developed largely on European-ancestry cohorts, with growing validation work elsewhere. We report the figure as a trend to track rather than an exact age, which is the appropriate way to use it in any population.

还有其他问题吗?

您的个人礼宾专员会在一个工作日内保密回复。

What this test does not tell you

  • It is not a diagnostic test. It does not detect cancer, cardiovascular disease or any specific condition.
  • Different clocks give different numbers. The gap between algorithms is expected and is why several are reported together.
  • A single reading carries measurement variation. Real change is judged from a baseline and a repeat measured the same way.
  • The evidence that lowering an epigenetic age lowers actual risk is not yet established. The marker is a tracker, not a proven target.
  • Reference populations used to train the clocks are not always Asian, so the age gap should be read as a trend rather than an exact figure.
  • Recent acute illness, infection or major stress can shift a reading. Timing matters, and your concierge will advise on it.

References

  1. [1] Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics. 2018;19(6):371-384.
  2. [2] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573-591.
  3. [3] Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327.
  4. [4] Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
  5. [5] Fitzgerald KN, Hodges R, Hanes D, et al. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021;13(7):9419-9432.

准备好添加 表观基因组 到您的长寿基准了吗?

您的个人健康礼宾专员将全程协调咨询、采样、解读和行动计划会议。

医学审核: Dr. Anthony Stanislaus, MBBS, PBM, Cert. Men's Health

最后审核 12 August 2026 · 下次审核 12 February 2027