Longevity pillar · Singapore
Epigenetic Biological Age Testing in Singapore
您的DNA序列在您的一生中几乎不会改变,但附着在DNA上的化学标签会随着饮食、睡眠、压力、运动和环境的变化而不断改变。读取这些标签可以告诉我们您的生物学年龄,它可能比您的实际年龄更年轻或更年长。
- SMC-registered doctors
- MOH-licensed clinic (HCSA)
- Mandarin Gallery, Orchard Road
- Weekdays 10am-7pm · Sat-Sun 10am-5pm
- 个人健康礼宾服务
时间年龄
45.0
生理年龄
42.3
生物学年龄: 42.3 对比实际年龄 45
Illustrative example, not a patient result.
测量内容
生物学年龄
根据数千个特定位点的 DNA 甲基化模式计算得出,估算您身体在分子层面的年龄。
年龄差
生物学年龄与实际年龄之间的差值——这是患者随时间推移追踪的核心指标。
检测原理
样本
唾液或血液,在单次门诊访问期间采集。
周转时间
Your personal health concierge confirms the reporting timeline for your laboratory when your sample is collected.
方法
在数千个 CpG 位点进行 DNA 甲基化分析,并通过同行评审的表观遗传时钟(GrimAge、PhenoAge)进行解读。
为何选择此方法
我们不依赖单一时钟。我们综合报告多种经过验证的算法,以便您和您的医生能够区分信号与噪声,并在 6-12 个月后通过基准测试与重复读数跟踪变化。
您将了解什么
- 您的生物学年龄是领先、落后还是与您的实际年龄一致。
- 您目前的衰老速度。
- 您所做的生活方式改变(训练、营养、睡眠、压力、补充剂)是否真正改善了您的生理状况。
- 哪些系统可能需要更多关注。
Why biological age matters for healthspan
Healthspan is the number of years you spend in good functional health, as distinct from lifespan. Epigenetic clocks were built to estimate that biological trajectory: they read chemical methylation marks on DNA and compare the pattern against reference populations of known age and health status.[1]
Second-generation clocks such as PhenoAge and GrimAge were trained not on chronological age but on clinical measures and outcomes, and in published cohort analyses an epigenetic age older than chronological age has been associated with higher risk of age-related disease and mortality.[2], [3]
A third-generation measure, DunedinPACE, reports the pace of ageing rather than a single age figure. It was developed from a cohort followed over decades and expresses how many biological years you accumulate per calendar year, which is the measure most sensitive to change between two readings.[4]
Methylation is responsive rather than fixed. Small randomised and pilot studies of diet, exercise, sleep and stress interventions have reported measurable movement in epigenetic age estimates, though the trials are early, small and not yet proof that changing the marker changes the outcome.[5]
These findings describe associations observed across populations, and epigenetic testing is a research-derived tool rather than a diagnostic. A result is a starting point and a way to track change over time, not a prediction about you as an individual.
Reading your report
生物学年龄
Your estimated age at the molecular level from each clock reported, shown next to your chronological age so the direction and size of the gap is clear.
年龄差
Biological age minus chronological age. A negative gap means your methylation pattern resembles people younger than you. This is the figure most patients track.
Pace of ageing
Where a pace measure is reported, a figure near 1.0 means roughly one biological year per calendar year. Above 1.0 is faster, below is slower.
Multiple clocks side by side
Different algorithms weight different sites, so they rarely agree exactly. Reporting several together shows whether a finding is signal or the quirk of one model.
System-level signals
Some clocks report component scores that flag which systems are contributing most to the gap, which helps direct the rest of your work-up.
Doctor's interpretation
Your result read against your bloods, body composition and history in the action-plan session. A number without that context is not a plan.
What moves the result
Sleep
Consistent duration and timing. Short and fragmented sleep is repeatedly associated with accelerated epigenetic age in observational cohorts.
Aerobic fitness and strength
Measured cardiorespiratory fitness and lean mass track with slower biological ageing estimates, which is why VO2 max and body composition are read alongside.
Body composition and metabolic health
Visceral fat, glucose regulation and lipid status are among the strongest correlates of second-generation clock output.
Nutrition quality
Dietary patterns rich in vegetables, adequate protein and methyl-donor nutrients feature in the small intervention trials reporting movement.
Alcohol and smoking
Both leave clear methylation signatures. Smoking status is directly weighted in GrimAge.
Chronic stress load
Sustained psychological stress and its hormonal consequences are associated with faster estimated ageing.
适用人群
- 任何进行重大生活方式投入并希望获得客观反馈的人。
- 正在接受激素、代谢或长寿治疗并追踪反应的患者。
- 40岁、50岁和60岁以上正在制定可衡量健康跨度计划的人群。
- 管理训练负荷和恢复的运动员及高绩效人士。
何时复测: 在积极做出改变期间,每6-12个月一次。单次读数只是一个快照;价值在于读数之间的变化。
它如何契合三大支柱
没有任何单一测试可以定义生物年龄。 表观基因组 与另外两大长寿数据支柱相辅相成——每一项都能揭示其他项无法提供的信息。将它们结合起来,即可获得当前医学所能提供的最完整图景。
Included in these tiers
Every tier includes a pre-test consultation, sample collection at our Orchard Road clinic, laboratory analysis, clinician-led interpretation, a written report and an action-plan session.
The Janus (The Baseline)
All-inclusive tier
The Apollo (The Functional)
All-inclusive tier
The Helios (The Performance)
All-inclusive tier
The Orion (The Complete)
All-inclusive tier
查看完整 长寿筛查套餐列表.
表观基因组 - 常见问题解答
由我们的临床团队撰写的清晰解答。点击任何问题即可获取其直接永久链接,如有其他疑问,请联系您的个人礼宾服务。
PhenoAge and GrimAge were trained on clinical measures and outcomes rather than on chronological age, so they estimate biological age in the context of health. Pace-of-ageing measures such as DunedinPACE report how fast you are ageing per calendar year rather than a single age figure, which makes them the most sensitive to change between two readings.
Chronological age counts birthdays. Biological age estimates how old your body looks at the molecular level based on methylation patterns. Two people born on the same day can sit years apart, and it is the gap and its direction over time that your doctor works with.
还有其他问题吗?
您的个人礼宾专员会在一个工作日内保密回复。
What this test does not tell you
- It is not a diagnostic test. It does not detect cancer, cardiovascular disease or any specific condition.
- Different clocks give different numbers. The gap between algorithms is expected and is why several are reported together.
- A single reading carries measurement variation. Real change is judged from a baseline and a repeat measured the same way.
- The evidence that lowering an epigenetic age lowers actual risk is not yet established. The marker is a tracker, not a proven target.
- Reference populations used to train the clocks are not always Asian, so the age gap should be read as a trend rather than an exact figure.
- Recent acute illness, infection or major stress can shift a reading. Timing matters, and your concierge will advise on it.
References
- [1] Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics. 2018;19(6):371-384.
- [2] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573-591.
- [3] Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327.
- [4] Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
- [5] Fitzgerald KN, Hodges R, Hanes D, et al. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021;13(7):9419-9432.
医学审核: Dr. Anthony Stanislaus, MBBS, PBM, Cert. Men's Health
最后审核 12 August 2026 · 下次审核 12 February 2027