Longevity pillar · Singapore
Epigenetic Biological Age Testing in Singapore
Huruf DNA anda hampir tidak berubah sepanjang hayat anda - tetapi tag kimia yang berada di atas DNA anda berubah secara berterusan sebagai tindak balas kepada diet, tidur, tekanan, senaman dan persekitaran. Membaca tag tersebut memberitahu kami usia biologi anda, yang boleh menjadi bertahun-tahun lebih muda atau lebih tua daripada usia kronologi anda.
- SMC-registered doctors
- MOH-licensed clinic (HCSA)
- Mandarin Gallery, Orchard Road
- Weekdays 10am-7pm · Sat-Sun 10am-5pm
- Penyambut tetamu kesihatan peribadi
Kronologi
45.0
Biologi
42.3
Usia biologi: 42.3 vs kronologi 45
Illustrative example, not a patient result.
Apa yang diukur
Usia biologi
Anggaran berapa usia badan anda pada tahap molekul, dikira daripada corak metilasi DNA di ribuan tapak khusus.
Jurang usia
Perbezaan antara usia biologi dan kronologi anda - nombor utama yang dijejaki pesakit dari semasa ke semasa.
Bagaimana ujian berfungsi
Sampel
Air liur atau darah, dikumpul semasa satu lawatan klinik.
Tempoh pusingan
Your personal health concierge confirms the reporting timeline for your laboratory when your sample is collected.
Kaedah
Pemprofilan metilasi DNA pada beribu-ribu tapak CpG, ditafsirkan melalui jam epigenetik yang disemak oleh rakan setara (GrimAge, PhenoAge).
Mengapa kaedah ini
Kami tidak bergantung pada satu jam sahaja. Pelbagai algoritma yang disahkan dilaporkan bersama supaya anda dan doktor anda boleh melihat isyarat berbanding hingar, kemudian menjejaki perubahan pada bacaan garis dasar + ulangan 6-12 bulan kemudian.
Apa yang anda akan pelajari
- Sama ada usia biologi anda mendahului, ketinggalan, atau selari dengan usia kronologi anda.
- Seberapa pantas anda sedang menua.
- Sama ada perubahan gaya hidup yang anda lakukan (latihan, pemakanan, tidur, tekanan, suplemen) benar-benar mengubah biologi anda.
- Sistem yang mana mungkin memerlukan perhatian lebih dekat.
Why biological age matters for healthspan
Healthspan is the number of years you spend in good functional health, as distinct from lifespan. Epigenetic clocks were built to estimate that biological trajectory: they read chemical methylation marks on DNA and compare the pattern against reference populations of known age and health status.[1]
Second-generation clocks such as PhenoAge and GrimAge were trained not on chronological age but on clinical measures and outcomes, and in published cohort analyses an epigenetic age older than chronological age has been associated with higher risk of age-related disease and mortality.[2], [3]
A third-generation measure, DunedinPACE, reports the pace of ageing rather than a single age figure. It was developed from a cohort followed over decades and expresses how many biological years you accumulate per calendar year, which is the measure most sensitive to change between two readings.[4]
Methylation is responsive rather than fixed. Small randomised and pilot studies of diet, exercise, sleep and stress interventions have reported measurable movement in epigenetic age estimates, though the trials are early, small and not yet proof that changing the marker changes the outcome.[5]
These findings describe associations observed across populations, and epigenetic testing is a research-derived tool rather than a diagnostic. A result is a starting point and a way to track change over time, not a prediction about you as an individual.
Reading your report
Usia biologi
Your estimated age at the molecular level from each clock reported, shown next to your chronological age so the direction and size of the gap is clear.
Jurang usia
Biological age minus chronological age. A negative gap means your methylation pattern resembles people younger than you. This is the figure most patients track.
Pace of ageing
Where a pace measure is reported, a figure near 1.0 means roughly one biological year per calendar year. Above 1.0 is faster, below is slower.
Multiple clocks side by side
Different algorithms weight different sites, so they rarely agree exactly. Reporting several together shows whether a finding is signal or the quirk of one model.
System-level signals
Some clocks report component scores that flag which systems are contributing most to the gap, which helps direct the rest of your work-up.
Doctor's interpretation
Your result read against your bloods, body composition and history in the action-plan session. A number without that context is not a plan.
What moves the result
Sleep
Consistent duration and timing. Short and fragmented sleep is repeatedly associated with accelerated epigenetic age in observational cohorts.
Aerobic fitness and strength
Measured cardiorespiratory fitness and lean mass track with slower biological ageing estimates, which is why VO2 max and body composition are read alongside.
Body composition and metabolic health
Visceral fat, glucose regulation and lipid status are among the strongest correlates of second-generation clock output.
Nutrition quality
Dietary patterns rich in vegetables, adequate protein and methyl-donor nutrients feature in the small intervention trials reporting movement.
Alcohol and smoking
Both leave clear methylation signatures. Smoking status is directly weighted in GrimAge.
Chronic stress load
Sustained psychological stress and its hormonal consequences are associated with faster estimated ageing.
Untuk siapa ini
- Sesiapa yang membuat pelaburan gaya hidup serius yang mahukan maklum balas objektif.
- Pesakit yang menjalani terapi hormon, metabolik atau umur panjang yang menjejaki tindak balas.
- Individu dalam lingkungan 40-an, 50-an dan 60-an yang membina pelan jangka hayat kesihatan yang boleh diukur.
- Atlet dan individu berprestasi tinggi yang menguruskan beban latihan dan pemulihan.
Bila perlu diulang: Setiap 6-12 bulan semasa anda aktif membuat perubahan. Satu bacaan hanyalah gambaran seketika; nilainya datang daripada perubahan antara bacaan.
Bagaimana ia sesuai dengan tiga tonggak
Tiada ujian tunggal yang menentukan usia biologi. The epigenom terletak di samping dua tonggak data jangka hayat yang lain - setiap satunya mendedahkan sesuatu yang tidak dapat ditunjukkan oleh yang lain. Gabungkan kesemuanya untuk gambaran paling lengkap yang boleh ditawarkan oleh perubatan semasa.
Included in these tiers
Every tier includes a pre-test consultation, sample collection at our Orchard Road clinic, laboratory analysis, clinician-led interpretation, a written report and an action-plan session.
The Janus (The Baseline)
All-inclusive tier
The Apollo (The Functional)
All-inclusive tier
The Helios (The Performance)
All-inclusive tier
The Orion (The Complete)
All-inclusive tier
Lihat penuh senarai pakej saringan jangka hayat.
Epigenome - soalan lazim
Jawapan yang jelas, ditulis oleh pasukan klinikal kami. Ketik mana-mana soalan untuk pautan kekal terusnya, atau hubungi Concierge Peribadi anda untuk perkara lain.
Jam yang kami gunakan telah disemak oleh rakan setara dan disahkan berbanding beribu-ribu sampel. Sebarang bacaan tunggal membawa sedikit variasi pengukuran - itulah sebabnya kami mengesyorkan bacaan asas ditambah bacaan ulangan 6-12 bulan kemudian untuk mengukur perubahan sebenar, bukan gangguan.
Kualiti tidur, latihan, pemakanan, komposisi badan, beban tekanan, alkohol, merokok, kesihatan metabolik, status hormon dan ubat-ubatan tertentu semuanya telah menunjukkan kesan yang boleh diukur dalam kajian yang diterbitkan. Sesi pelan tindakan anda menterjemahkan keputusan anda kepada tuas khusus yang paling mungkin penting untuk anda.
PhenoAge and GrimAge were trained on clinical measures and outcomes rather than on chronological age, so they estimate biological age in the context of health. Pace-of-ageing measures such as DunedinPACE report how fast you are ageing per calendar year rather than a single age figure, which makes them the most sensitive to change between two readings.
Chronological age counts birthdays. Biological age estimates how old your body looks at the molecular level based on methylation patterns. Two people born on the same day can sit years apart, and it is the gap and its direction over time that your doctor works with.
Masih mempunyai soalan?
Concierge Peribadi anda akan membalas dalam tempoh satu hari bekerja - secara sulit.
What this test does not tell you
- It is not a diagnostic test. It does not detect cancer, cardiovascular disease or any specific condition.
- Different clocks give different numbers. The gap between algorithms is expected and is why several are reported together.
- A single reading carries measurement variation. Real change is judged from a baseline and a repeat measured the same way.
- The evidence that lowering an epigenetic age lowers actual risk is not yet established. The marker is a tracker, not a proven target.
- Reference populations used to train the clocks are not always Asian, so the age gap should be read as a trend rather than an exact figure.
- Recent acute illness, infection or major stress can shift a reading. Timing matters, and your concierge will advise on it.
References
- [1] Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics. 2018;19(6):371-384.
- [2] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573-591.
- [3] Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327.
- [4] Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
- [5] Fitzgerald KN, Hodges R, Hanes D, et al. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021;13(7):9419-9432.
Sedia untuk menambah epigenom ke garis dasar jangka hayat anda?
Concierge kesihatan peribadi anda menyelaras sesi rundingan, pensampelan, tafsiran dan pelan tindakan dari awal hingga akhir.
Disemak secara perubatan oleh Dr. Anthony Stanislaus, MBBS, PBM, Cert. Men's Health
Terakhir disemak 12 August 2026 · Semakan seterusnya 12 February 2027