Longevity pillar · Singapore
Epigenetic Biological Age Testing in Singapore
Huruf DNA Anda hampir tidak berubah sepanjang hidup Anda - tetapi penanda kimia di atas DNA Anda terus bergeser sebagai respons terhadap pola makan, tidur, stres, olahraga, dan lingkungan. Membaca penanda tersebut memberi tahu kami usia biologis Anda, yang bisa bertahun-tahun lebih muda atau lebih tua dari usia kronologis Anda.
- SMC-registered doctors
- MOH-licensed clinic (HCSA)
- Mandarin Gallery, Orchard Road
- Weekdays 10am-7pm · Sat-Sun 10am-5pm
- Pramutamu kesehatan pribadi
Kronologis
45.0
Biologis
42.3
Usia biologis: 42.3 vs kronologis 45
Illustrative example, not a patient result.
Apa yang diukur
Usia biologis
Perkiraan seberapa tua tubuh Anda terlihat pada tingkat molekuler, dihitung dari pola metilasi DNA di ribuan lokasi spesifik.
Selisih usia
Perbedaan antara usia biologis dan kronologis Anda - angka utama yang dilacak pasien dari waktu ke waktu.
Cara kerja tes
Sampel
Air liur atau darah, dikumpulkan selama satu kunjungan klinik.
Waktu pengerjaan
Your personal health concierge confirms the reporting timeline for your laboratory when your sample is collected.
Metode
Pemetaan metilasi DNA di ribuan situs CpG, diinterpretasikan melalui jam epigenetik yang telah ditinjau sejawat (GrimAge, PhenoAge).
Mengapa metode ini
Kami tidak mengandalkan satu jam saja. Beberapa algoritma yang tervalidasi dilaporkan bersamaan agar Anda dan dokter Anda dapat melihat sinyal vs kebisingan, kemudian melacak perubahan pada pembacaan dasar + ulangan 6-12 bulan kemudian.
Apa yang akan Anda pelajari
- Apakah usia biologis Anda lebih maju, lebih lambat, atau sejalan dengan usia kronologis Anda.
- Seberapa cepat Anda menua saat ini.
- Apakah perubahan gaya hidup yang Anda lakukan (pelatihan, nutrisi, tidur, stres, suplemen) benar-benar mengubah biologi Anda.
- Sistem mana yang mungkin memerlukan perhatian lebih dekat.
Why biological age matters for healthspan
Healthspan is the number of years you spend in good functional health, as distinct from lifespan. Epigenetic clocks were built to estimate that biological trajectory: they read chemical methylation marks on DNA and compare the pattern against reference populations of known age and health status.[1]
Second-generation clocks such as PhenoAge and GrimAge were trained not on chronological age but on clinical measures and outcomes, and in published cohort analyses an epigenetic age older than chronological age has been associated with higher risk of age-related disease and mortality.[2], [3]
A third-generation measure, DunedinPACE, reports the pace of ageing rather than a single age figure. It was developed from a cohort followed over decades and expresses how many biological years you accumulate per calendar year, which is the measure most sensitive to change between two readings.[4]
Methylation is responsive rather than fixed. Small randomised and pilot studies of diet, exercise, sleep and stress interventions have reported measurable movement in epigenetic age estimates, though the trials are early, small and not yet proof that changing the marker changes the outcome.[5]
These findings describe associations observed across populations, and epigenetic testing is a research-derived tool rather than a diagnostic. A result is a starting point and a way to track change over time, not a prediction about you as an individual.
Reading your report
Usia biologis
Your estimated age at the molecular level from each clock reported, shown next to your chronological age so the direction and size of the gap is clear.
Selisih usia
Biological age minus chronological age. A negative gap means your methylation pattern resembles people younger than you. This is the figure most patients track.
Pace of ageing
Where a pace measure is reported, a figure near 1.0 means roughly one biological year per calendar year. Above 1.0 is faster, below is slower.
Multiple clocks side by side
Different algorithms weight different sites, so they rarely agree exactly. Reporting several together shows whether a finding is signal or the quirk of one model.
System-level signals
Some clocks report component scores that flag which systems are contributing most to the gap, which helps direct the rest of your work-up.
Doctor's interpretation
Your result read against your bloods, body composition and history in the action-plan session. A number without that context is not a plan.
What moves the result
Sleep
Consistent duration and timing. Short and fragmented sleep is repeatedly associated with accelerated epigenetic age in observational cohorts.
Aerobic fitness and strength
Measured cardiorespiratory fitness and lean mass track with slower biological ageing estimates, which is why VO2 max and body composition are read alongside.
Body composition and metabolic health
Visceral fat, glucose regulation and lipid status are among the strongest correlates of second-generation clock output.
Nutrition quality
Dietary patterns rich in vegetables, adequate protein and methyl-donor nutrients feature in the small intervention trials reporting movement.
Alcohol and smoking
Both leave clear methylation signatures. Smoking status is directly weighted in GrimAge.
Chronic stress load
Sustained psychological stress and its hormonal consequences are associated with faster estimated ageing.
Untuk siapa ini
- Siapa pun yang melakukan investasi gaya hidup serius dan menginginkan umpan balik objektif.
- Pasien yang menjalani terapi hormon, metabolik, atau umur panjang yang melacak respons.
- Orang berusia 40-an, 50-an, dan 60-an yang sedang menyusun rencana rentang kesehatan yang terukur.
- Atlet dan individu berkinerja tinggi yang mengelola beban latihan dan pemulihan.
Kapan harus mengulang: Setiap 6-12 bulan saat Anda aktif melakukan perubahan. Satu kali pemeriksaan hanyalah sebuah gambaran; nilainya berasal dari perubahan antar pemeriksaan.
Bagaimana ini sesuai dengan tiga pilar
Tidak ada satu tes pun yang menentukan usia biologis. epigenome berdampingan dengan dua pilar data umur panjang lainnya - masing-masing mengungkapkan sesuatu yang tidak dapat diungkapkan oleh yang lain. Gabungkan ketiganya untuk mendapatkan gambaran paling lengkap yang dapat ditawarkan oleh pengobatan saat ini.
Included in these tiers
Every tier includes a pre-test consultation, sample collection at our Orchard Road clinic, laboratory analysis, clinician-led interpretation, a written report and an action-plan session.
The Janus (The Baseline)
All-inclusive tier
The Apollo (The Functional)
All-inclusive tier
The Helios (The Performance)
All-inclusive tier
The Orion (The Complete)
All-inclusive tier
Lihat lengkap daftar paket pemeriksaan umur panjang.
Epigenom - pertanyaan yang sering diajukan
Jawaban jelas, ditulis oleh tim klinis kami. Ketuk pertanyaan apa pun untuk mendapatkan tautan langsungnya, atau hubungi Personal Concierge Anda untuk hal lainnya.
Jam yang kami gunakan telah ditinjau oleh rekan sejawat dan divalidasi terhadap ribuan sampel. Setiap pembacaan tunggal memiliki variasi pengukuran - itulah sebabnya kami merekomendasikan pembacaan dasar ditambah pembacaan ulang 6-12 bulan kemudian untuk mengukur perubahan nyata, bukan sekadar gangguan data.
Kualitas tidur, latihan, nutrisi, komposisi tubuh, beban stres, alkohol, merokok, kesehatan metabolik, status hormon, dan obat-obatan tertentu telah menunjukkan efek terukur dalam studi yang dipublikasikan. Sesi rencana aksi Anda menerjemahkan hasil Anda menjadi faktor spesifik yang paling mungkin memengaruhi Anda.
PhenoAge and GrimAge were trained on clinical measures and outcomes rather than on chronological age, so they estimate biological age in the context of health. Pace-of-ageing measures such as DunedinPACE report how fast you are ageing per calendar year rather than a single age figure, which makes them the most sensitive to change between two readings.
Chronological age counts birthdays. Biological age estimates how old your body looks at the molecular level based on methylation patterns. Two people born on the same day can sit years apart, and it is the gap and its direction over time that your doctor works with.
Masih punya pertanyaan?
Concierge Pribadi Anda akan membalas dalam satu hari kerja - secara rahasia.
What this test does not tell you
- It is not a diagnostic test. It does not detect cancer, cardiovascular disease or any specific condition.
- Different clocks give different numbers. The gap between algorithms is expected and is why several are reported together.
- A single reading carries measurement variation. Real change is judged from a baseline and a repeat measured the same way.
- The evidence that lowering an epigenetic age lowers actual risk is not yet established. The marker is a tracker, not a proven target.
- Reference populations used to train the clocks are not always Asian, so the age gap should be read as a trend rather than an exact figure.
- Recent acute illness, infection or major stress can shift a reading. Timing matters, and your concierge will advise on it.
References
- [1] Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics. 2018;19(6):371-384.
- [2] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573-591.
- [3] Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327.
- [4] Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
- [5] Fitzgerald KN, Hodges R, Hanes D, et al. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021;13(7):9419-9432.
Siap untuk menambahkan epigenome ke garis dasar umur panjang Anda?
Concierge kesehatan pribadi Anda mengoordinasikan konsultasi, pengambilan sampel, interpretasi, dan sesi rencana tindakan dari awal hingga akhir.
Ditinjau secara medis oleh Dr. Anthony Stanislaus, MBBS, PBM, Cert. Men's Health
Terakhir ditinjau 12 August 2026 · Tinjauan berikutnya 12 February 2027